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In Alb-uPA mice, uPA is structurally expressed in hepatocytes under the control of an albumin promoter, leading to intracellular lysis of plasminogen into active plasmin, causing proteolysis within hepatocytes, promoting activation of apoptosis, and ultimately leading to persistent liver damage and failure
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It is billed to Medicare Part B and most commercial payers when a patient receives a medically necessary cyanocobalamin injection for conditions such as pernicious anemia or documented B12 deficiency